Health researchers said on Thursday they had found a troubling link between higher consumption of rice and Type 2 diabetes, a disease that in some countries is becoming an epidemic.
Further work is need to probe the apparent association and diets that are notoriously high in sugar and fats should remain on the no-go list, they cautioned.
"What we've found is white rice is likely to increase the risk of Type 2 diabetes, especially at high consumption levels such as in Asian populations," Qi Sun of the Harvard School of Public Health told AFP.
"But at the same time people should pay close attention to the other things they eat.
"It's very important to address not just a single food but the whole pattern of consumption."
In the British Medical Journal (BMJ), Sun's team said the link emerged from an analysis of four previously published studies, carried out in China, Japan, Australia and the United States.
These studies followed 350,000 people over a timescale from four to 22 years. More than 13,000 people developed Type 2 diabetes.
In the studies carried out in China and Japan, those who ate most rice were 55 percent likelier to develop the disease than those who ate least. In the United States and Australia, where consumption of rice is far lower, the difference was 12 percent.
Participants in the two Asian countries ate three or four servings of rice a day on average, compared to just one or two servings a week in the Western countries.
White rice is the dominant form of rice eaten in the world. Machines produce its polished look by hulling and milling, leaving a grain that is predominantly starch.
Brown rice, by contrast, has more fibre, magnesium and vitamins, and a lower "glycaemic index," a measurement of sugar content, than white rice.
Sun said the study did have limitations, including full details about what the volunteers ate in addition to rice.
"I don't think I can put forward a 100-percent confirmed case, given that this is a meta-analysis of four original studies," he said.
"But I see a consistency across these studies, and there is biological plausibility that supports the association between white rice consumption and diabetes."
He added: "More trial data are needed to corroborate or refute our observations."
Diabetes affects nearly 350 million adults worldwide, according to the US Centers for Disease Control and Prevention (CDC).
Diet is only one factor in Type 2 diabetes, a complex disease that involves high levels of blood sugar that cannot be processed by the hormone insulin. Obesity and lack of exercise are also cited as culprits.