And they're off - day five in man vs the bulls.
Here in Pamplona, Spain, the bulls seem to be winning - the latest victim- a man towards the end- knocked unconscious.
But he was pretty lucky as revellers in previous days have seen the wrong end of a horn.
Each day the bulls hail from a different region - to find the most fierce.
Last Tuesday was no exception, which saw two runners gored - one critically.
Some called brave - others- well- less intelligent - take part in the San Fermin festival made famous by Ernest Hemingway's novel 'The Sun Also Rises.'
Weekend holiday makers swelled the runners' ranks but still managed a brisk three minute two seconds race.
For those wanting to tempt fate - they only have two more chances as the last run is Tuesday.