Russian President Vladimir Putin will meet with Turkish Prime Minister Recep Tayyip Erdogan during a landmark visit to Istanbul on Monday to discuss the crisis in Syria.
The visit, which marks Putin's first trip outside Russia since he visited Tajikistan on October 5, has been confirmed by both Turkish and Russian officials.
Syria is expected to figure high on the agenda during Putin's talks with Turkish leaders.
"The negotiations are to touch upon a series of urgent international and regional issues including reconciliation in the Middle East, the situation in the Gaza Strip, the crisis in Syria, as well as cooperation," Putin's foreign policy aide Yury Ushakov said in a statement.
In Istanbul, Putin will co-chair with Turkey's Erdogan a high-level cooperation council meeting, a mechanism established between the two countries to foster ties in every sphere.
After that meeting, there is a telephone conversation scheduled between Putin and Turkish President Abdullah Gul, the Russian aide said.
Despite their divergences on some issues, the two countries enjoy growing trade and energy links.
Turkey depends on Russia for most of its natural gas and oil supplies. In 2010, Ankara struck a deal with Moscow to build the country's first nuclear power plant at Akkuyu in the southern Mersin province.
After the Istanbul meeting, both countries are expected to sign a number of agreements including a memorandum of understanding in the sphere of banking and finance.